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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK4
All Species:
12.12
Human Site:
S372
Identified Species:
20.51
UniProt:
Q9NR20
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NR20
NP_003836.1
520
59608
S372
V
L
K
T
Y
D
T
S
F
L
D
F
L
R
R
Chimpanzee
Pan troglodytes
XP_001158495
520
59654
S372
V
L
K
T
Y
D
T
S
F
L
D
F
L
R
R
Rhesus Macaque
Macaca mulatta
XP_001101112
520
59434
S372
V
I
R
P
Y
H
Y
S
L
L
F
F
Q
M
D
Dog
Lupus familis
XP_534917
565
65190
T416
D
L
T
M
V
L
K
T
Y
D
T
S
F
L
D
Cat
Felis silvestris
Mouse
Mus musculus
Q8BI55
632
72542
T483
D
L
T
M
V
V
K
T
Y
D
S
S
F
L
D
Rat
Rattus norvegicus
Q4V8A3
586
65492
P428
M
E
L
L
G
M
P
P
Q
K
L
L
E
Q
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509988
466
52101
E319
S
L
G
C
I
L
A
E
L
N
T
G
S
P
L
Chicken
Gallus gallus
Q5ZIU3
526
59419
A377
L
L
D
S
S
K
R
A
K
N
F
V
S
S
K
Frog
Xenopus laevis
Q2TAE3
750
84138
S510
T
S
S
S
S
G
G
S
S
G
T
S
N
S
G
Zebra Danio
Brachydanio rerio
XP_693389
634
72240
L480
V
L
K
T
N
D
P
L
F
L
D
F
I
Q
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3D5
722
79590
Y466
I
L
H
C
Q
D
R
Y
F
I
D
F
L
Q
R
Honey Bee
Apis mellifera
XP_396369
614
68978
L448
A
L
R
C
T
D
T
L
F
V
D
F
V
R
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51568
400
46206
V253
N
R
I
H
H
S
I
V
Q
T
R
H
Y
R
S
Baker's Yeast
Sacchar. cerevisiae
P14680
807
91227
P637
E
Y
N
I
V
E
K
P
S
K
Q
Y
F
K
W
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.8
89.2
76.9
N.A.
65.3
38.7
N.A.
54.2
43.1
28
48.9
N.A.
37.5
42.3
N.A.
N.A.
Protein Similarity:
100
99
91.5
81.2
N.A.
71.5
53.9
N.A.
66.1
59.7
43.3
61.8
N.A.
50.1
59.1
N.A.
N.A.
P-Site Identity:
100
100
33.3
6.6
N.A.
6.6
0
N.A.
6.6
6.6
6.6
66.6
N.A.
46.6
53.3
N.A.
N.A.
P-Site Similarity:
100
100
46.6
20
N.A.
20
13.3
N.A.
6.6
33.3
13.3
80
N.A.
66.6
73.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.8
22.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
42.5
36.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
8
8
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
22
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
15
0
8
0
0
36
0
0
0
15
36
0
0
0
22
% D
% Glu:
8
8
0
0
0
8
0
8
0
0
0
0
8
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
36
0
15
43
22
0
0
% F
% Gly:
0
0
8
0
8
8
8
0
0
8
0
8
0
0
8
% G
% His:
0
0
8
8
8
8
0
0
0
0
0
8
0
0
0
% H
% Ile:
8
8
8
8
8
0
8
0
0
8
0
0
8
0
0
% I
% Lys:
0
0
22
0
0
8
22
0
8
15
0
0
0
8
8
% K
% Leu:
8
65
8
8
0
15
0
15
15
29
8
8
22
15
8
% L
% Met:
8
0
0
15
0
8
0
0
0
0
0
0
0
8
0
% M
% Asn:
8
0
8
0
8
0
0
0
0
15
0
0
8
0
0
% N
% Pro:
0
0
0
8
0
0
15
15
0
0
0
0
0
8
0
% P
% Gln:
0
0
0
0
8
0
0
0
15
0
8
0
8
22
0
% Q
% Arg:
0
8
15
0
0
0
15
0
0
0
8
0
0
29
36
% R
% Ser:
8
8
8
15
15
8
0
29
15
0
8
22
15
15
15
% S
% Thr:
8
0
15
22
8
0
22
15
0
8
22
0
0
0
0
% T
% Val:
29
0
0
0
22
8
0
8
0
8
0
8
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% W
% Tyr:
0
8
0
0
22
0
8
8
15
0
0
8
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _